LUX -- A Laser-Plasma Driven Undulator Beamline

The LUX beamline is a novel type of laser-plasma accelerator. Building on the joint expertise of the University of Hamburg and DESY the beamline was carefully designed to combine state-of-the-art expertise in laser-plasma acceleration with the latest advances in accelerator technology and beam diagnostics. LUX introduces a paradigm change moving from single-shot demonstration experiments towards available, stable and controllable accelerator operation. Here, we discuss the general design concepts of LUX and present first critical milestones that have recently been achieved, including the generation of electron beams at the repetition rate of up to 5 Hz with energies above 600 MeV and the generation of spontaneous undulator radiation at a wavelength well below 9 nm.Comment: submitte

Design considerations for table-top, laser-based VUV and X-ray free electron lasers

A recent breakthrough in laser-plasma accelerators, based upon ultrashort high-intensity lasers, demonstrated the generation of quasi-monoenergetic GeV-electrons. With future Petawatt lasers ultra-high beam currents of ~100 kA in ~10 fs can be expected, allowing for drastic reduction in the undulator length of free-electron-lasers (FELs). We present a discussion of the key aspects of a table-top FEL design, including energy loss and chirps induced by space-charge and wakefields. These effects become important for an optimized table-top FEL operation. A first proof-of-principle VUV case is considered as well as a table-top X-ray-FEL which may open a brilliant light source also for new ways in clinical diagnostics.Comment: 6 pages, 4 figures; accepted for publication in Appl. Phys.

Golden gravitational lensing systems from the Sloan Lens ACS Survey. I. SDSS J1538+5817: one lens for two sources

We present a lensing and photometric study of the exceptional system SDSS J1538+5817, identified by the SLACS survey. The lens is a luminous elliptical at redshift z=0.143. Using HST public images in two different filters, the presence of two background sources lensed into an Einstein ring and a double system is ascertained. Our new spectroscopic observations, performed at the NOT, reveal that the two sources are located at the same redshift z=0.531. We investigate the total mass distribution of the lens between 1 and 4 kpc from the galaxy center by means of parametric and non-parametric lensing codes that describe the multiple images as point-like objects. Several disparate lensing models agree on: (1) reproducing accurately the observed image positions; (2) predicting a nearly axisymmetric total mass distribution, centered and oriented as the light distribution; (3) measuring a value of 8.11 x 10^{10} M_{Sun} for the total mass projected within the Einstein radius of 2.5 kpc; (4) estimating a total mass density profile slightly steeper than an isothermal one. A fit of the SDSS multicolor photometry with CSP models provides a value of 20 x 10^{10} M_{Sun} for the total stellar mass of the galaxy and of 0.9 for the fraction of projected luminous over total mass enclosed inside the Einstein radius. By combining lensing and photometric mass measurements, we differentiate the lens mass content in terms of luminous and dark matter components. This two-component modeling, which is viable only in extraordinary systems like SDSS J1538+5817, leads to a description of the global properties of the galaxy dark matter halo. Extending these results to a larger number of lenses would improve considerably our understanding of galaxy formation and evolution processes in the LCDM scenario.Comment: 21 pages, 16 figures, accepted by The Astrophysical Journa

Molecular and Genetic Crosstalks between mTOR and ERRα Are Key Determinants of Rapamycin-Induced Nonalcoholic Fatty Liver

SummarymTOR and ERRα are key regulators of common metabolic processes, including lipid homeostasis. However, it is currently unknown whether these factors cooperate in the control of metabolism. ChIP-sequencing analyses of mouse liver reveal that mTOR occupies regulatory regions of genes on a genome-wide scale including enrichment at genes shared with ERRα that are involved in the TCA cycle and lipid biosynthesis. Genetic ablation of ERRα and rapamycin treatment, alone or in combination, alter the expression of these genes and induce the accumulation of TCA metabolites. As a consequence, both genetic and pharmacological inhibition of ERRα activity exacerbates hepatic hyperlipidemia observed in rapamycin-treated mice. We further show that mTOR regulates ERRα activity through ubiquitin-mediated degradation via transcriptional control of the ubiquitin-proteasome pathway. Our work expands the role of mTOR action in metabolism and highlights the existence of a potent mTOR/ERRα regulatory axis with significant clinical impact